Evaluation of the stability of creatine in solution prepared from effervescent creatine formulations authors authors and affiliations (hplc) intrinsic dissolution and saturated solubility of creatine, creatine monohydrate, and di-creatine citrate in water were determined and compared camazzo j, stout jr: evaluation of creatine. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated(creatine monohydrate) section 12: ecological information. Our data suggest that creatine monohydrate use for 10 weeks did not produce any effects on 1-rm squat strength, urinary creatinine concentration, or body composition in collegiate football players the 1-rm strength increased in all groups. Andre, thomas l, et al effects of five weeks of resistance training and relatively-dosed creatine monohydrate supplementation on body composition and muscle strength, and whole-body creatine metabolism in resistance-trained males.
1 introductioncreatine is an amino acid derivative normally produced in the liver, kidneys and pancreas from glycine, arginine and methionine it increases the bioavailability of phosphocreatine, a molecular component necessary for the production of cellular adenosine triphosphate. To date there have been no evidence-based scientific studies to prove that any other chemical form of creatine is more effective as creatine monohydrate (4) even so-called ‘buffered’ ie alkaline creatine, which is supposed to lead to a higher level of creatine storage in the muscle due to a higher bioavailability, could not be confirmed. Creatine use can increase maximum power and performance in high-intensity anaerobic repetitive work (periods of work and rest) by 5 to 15%    creatine has no significant effect on aerobic endurance , though it will increase power during short sessions of high-intensity aerobic exercise.
Creatine monohydrate supplementation does not augment fitness, performance, or body composition adaptations in response to four weeks of high-intensity interval training in young females int j sport nutr exerc metab 2017 jun27:285-92. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication the information given is designed only as a guidance for safe handling, use, processing, storage. So, what is creatine monohydrate exactly as far as its chemical composition, it’s very similar to an amino acid in fact, the body synthesizes creatine from two amino acids, glycine and arginine. Micronized creatine is essentially creatine monohydrate, but with much smaller molecules (this creatine has been micronized, which means its molecules have been cut up or divided) this dividing or cutting reduced the surface area of the creatine, making it easier to absorb and lessening any potential stomach discomfort. New forms of creatine have been introduced into the marketplace by supplement manufacturers that claimed to have better physical and chemical properties, bioavailability, efficacy, and safety profiles than creatine monohydrate 1.
The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition , effect of a 10-week strength training program and recovery drink on body composition, muscular strength and joe carnazzo and jeffrey r stout, evaluation of creatine transport using caco‐2 monolayers as an in vitro model. P 1 1 2 0 he alth fire re activity pe rs onal prote ction 2 1 0 e material safety data sheet creatine monohydrate msds section 1: chemical product and company identification. Creatine monohydrate for use in foods for particular nutritional uses a report on the composition and specification of food intended to meet the expenditure of intense evaluation of cm as a nutrient source for creatine in practice includes evaluation of the purity of. Creatine monohydrate is a well-known basic creatine supplement easy to find and inexpensive, creatine monohydrate is a favorite of many supplement users numerous scientific studies verify the useful effects and benefits of creatine monohydrate however, there are drawbacks that make it a less-than-perfect option. Creatine monohydrate is the monohydrate form of creatine similar or identical to endogenous creatine produced in the liver, kidneys, and pancreas creatine , in phosphate form, helps supply energy to muscle cells for contraction.
A buffered form of creatine does not promote greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrate journal of the international society of sports nutrition, 9:43. Creatine monohydrate is the most common form of creatine, and if not otherwise mentioned is the default form of creatine used in most studies on creatine it has fairly decent intestinal absorption   (covered more in depth in the pharmacology section) and is the standard form or “reference” form of creatine, which all other variants. An estimated 40% of college athletes and up to half of professional athletes say they use creatine supplements creatine is thought to improve strength, increase lean muscle mass, and help the. California athletic trainers association meeting, 10/26/99 these are my lecture notes that i used in my presentation creatine was discovered in 1835 by a french scientist, chevreul, who isolated creatine in meat extracts 54 chemical name is methyl guanido-acetic acid.
14 c‐creatine monohydrate permeability across caco‐2 monolayers was examined in both the apical to basolateral (a–b) and the basolateral to apical (b–a) direction, and is depicted in figure 2whereas the permeability of 14 c‐creatine was low in both directions, the b–a transfer of the compound was significantly greater than the a–b transfer. The supplementation of standard diets with creatine-based compounds in speed-and-strength sports has become very popular today the creatine alone is an endogenous substance synthetized in internal organs, such as liver, pancreas and kidneys. Product overview strengthseries creatine hmb includes ingredients at clinically effective dosages and contains zero artificial sweeteners, colored dyes, unnecessary fillers, or harmful additives when combined, creapure® (creatine monohydrate) and hmb have been shown to enhance strength, increase endurance, decrease fa. Greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrate chemical properties, bioavailability, efficacy, and/or safety profiles than creatine monohydrate  however, there is little to no evidence that any of the newer forms.